Is a lower dose of cetrorelix acetate effective for prevention of LH surge during controlled ovarian hyperstimulation?

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GnRH antagonist, cetrorelix, for pituitary suppression in modern, patient-friendly assisted reproductive technology.

BACKGROUND Gonadotropin-releasing hormone (GnRH) analogues are used routinely to prevent a premature luteinizing hormone (LH) surge in women undergoing assisted reproductive technology (ART) treatments. In contrast to GnRH agonists, antagonists produce rapid and reversible suppression of LH with no initial flare effect. OBJECTIVE To review the role of cetrorelix, the first GnRH antagonist app...

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Controlled Ovarian Hyperstimulation with Intrauterine Insemination Is More Successful After r-hCG Administration Than Spontaneous LH Surge

BACKGROUND The purpose of this study was to evaluate whether clinical pregnancy rate is affected by timing intrauterine insemination (IUI) according to serum LH surge, r-hCG trigger, or a combination of LH surge and r-hCG trigger in controlled ovarian hyperstimulation (COH) cycles for patients with a variety of infertility etiologies. METHODS The last 365 consecutive COH-IUI cycles performed ...

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Renal and Hepatic Functions After a Week of Controlled Ovarian Hyperstimulation During In Vitro Fertilization Cycles

Background One the main aspects of an in vitro fertilization (IVF) cycle is to avoid any possible systemic damage to women undergoing to a controlled ovarian hyperstimulation (COH). The aim of this work is to evaluate renal and hepatic function blood tests in patients undergoing controlled ovarian hyperstimulation during IVF cycles. MaterialsAndMethods All patients received a long stimulation p...

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Dose-finding study of triptorelin acetate for prevention of a premature LH surge in IVF: a prospective, randomized, double-blind, placebo-controlled study.

Gonadotrophin-releasing hormone agonists (GnRHa) are routinely used in IVF programmes to prevent an unwanted LH surge and consequent ovulation. Despite its widespread use in IVF, a convincing dose recommendation for GnRHa in IVF does not exist. In our opinion, the lowest possible dose of GnRHa should be used. Thus, we performed a prospective, randomized, double-blind, placebo-controlled study t...

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Prevention of Ovarian Hyperstimulation Syndrome

Ovarian hyperstimulation syndrome (OHSS) is rare but most serious complication of ovarian stimulation. Symptoms are mainly related to increased capillary permeability leading to extravasation of fluid into extravascular compartment. Disease pathophysiology is linked to hCG (human chorionic gonadotropin) which acts through angiogenic molecule vascular endothelial growth factor (VEGF). There is r...

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ژورنال

عنوان ژورنال: Journal of Assisted Reproduction and Genetics

سال: 2006

ISSN: 1058-0468,1573-7330

DOI: 10.1007/s10815-006-9054-0