Is it severe asthma or asthma with severe comorbidities?

Is it severe asthma or asthma with severe comorbidities?

Severe asthma is defined as asthma that requires treatment with high-dose inhaled corticosteroids (ICSs) plus a second controller and/or systemic corticosteroids to prevent it from becoming uncontrolled or that remains uncontrolled despite this therapy. This definition has limitations: 1) it does not define any biological characteristic that distinguishes severe asthma from asthma in general an...

Severe asthma is really uncommon

We describe the case of a 10-year-old girl with a history of severe persistent asthma and exercise-induced-asthma, controlled using an appropriate treatment with inhaled corticosteroid-long-acting beta-2 adrenergic agonists (ICS+LABA) and leukotriene receptor antagonists. She was healthy until the age of 8 years, when she presented two episodes of radiologically diagnosed pneumonia. After that,...

[Severe asthma].

pneumomediastinum is a possible acute complication of severe occupational asthma

occupational asthma has been reported  to  be the most  common  chronic respiratory occupational disease in many developed countries, and  as with other  occupational lung diseases, occupational asthma is potentially preventable. we report  the case of a 24-year-old baker who experienced pneumomediastinum as a consequence of workplace exposure. this is the first report of pneumomediastinum as a...

Severe asthma is an epithelial disease.

A sthma is an important, clinically prevalent disease worldwide. Despite a better knowledge on the pathogenesis, the mechanisms underlying the induction and persistence of the disease are largely unknown. It is now accepted that airway inflammation and structural changes of the bronchi are important features. The relationships between those structural changes and clinical and functional abnorma...