Is lipid oxidation essential for atherogenesis?

Is lipid oxidation essential for atherogenesis?

Lipid oxidation in atherogenesis: an overview.

The 'oxidation theory' for atherosclerosis proposes that lipid and/or protein oxidation products are responsible for lesion formation/development. The major target for oxidation is suggested to be intimal low-density lipoprotein. This idea was stimulated by the pro-atherogenic properties of in vitro oxidized lipoproteins, such as stimulation of chemotaxis and sterol accumulation in macrophages,...

Mitochondrial fat oxidation is essential for lipid-induced inflammation in skeletal muscle in mice

Inflammation, lipotoxicity and mitochondrial dysfunction have been implicated in the pathogenesis of obesity-induced insulin resistance and type 2 diabetes. However, how these factors are intertwined in the development of obesity/insulin resistance remains unclear. Here, we examine the role of mitochondrial fat oxidation on lipid-induced inflammation in skeletal muscle. We used skeletal muscle-...

The Oxidation Hypothesis of Atherogenesis

For more than two decades, there has been continuing evidence of lipid oxidation playing a central role in atherogenesis. The oxidation hypothesis of atherogenesis has evolved to focus on specific pro-inflammatory oxidized phospholipids, which result from the oxidation of LDL phospholipids containing arachidonic acid, and which are recognized by the innate immune system in animals and humans. T...

MicroRNAs regulating lipid metabolism in atherogenesis.

MicroRNAs have emerged as important post-transcriptional regulators of lipid metabolism, and represent a new class of targets for therapeutic intervention. Recently, microRNA-33a and b (miR-33a/b) were discovered as key regulators of metabolic programs including cholesterol and fatty acid homeostasis. These intronic microRNAs are embedded in the sterol response element binding protein genes, S...