Is the Ki-67 labelling index ready for clinical use?
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چکیده
منابع مشابه
Is the Ki-67 labelling index ready for clinical use?
editorial Is the Ki-67 labelling index ready for clinical use? Cancer is one of the leading causes of death worldwide. Identification of biomarkers that can detect cancer early, monitor disease progression or serve as a surrogate marker for prognosis and prediction will enable us to personalise medicine and improve care of cancer patients. Up to now, the leading parameters that define treatment...
متن کاملClinical Significance of Ki-67 Labeling Index in Pituitary Macroadenoma
The aim of our study was to investigate the correlation of the proliferative activity of pituitary neoplasms with clinical characteristics and recurrences. Tumor specimens were obtained from 44 consecutive patients with pituitary macroadenomas who underwent surgery between July 1998 and August 2003. Specimens were immediately fixed in 10% buffered formalin and then embedded in paraffin. The Ki-...
متن کاملKi-67 labelling index and invasiveness among anterior pituitary adenomas: analysis of 103 cases using the MIB-1 monoclonal antibody.
AIMS To investigate the relation between proliferative activity of anterior pituitary adenomas, quantified by the Ki-67 labelling index, and their invasive behaviour. METHODS Expression of Ki-67 was evaluated in 103 anterior pituitary adenomas consecutively operated on in a 36 month period and correlated with surgical evidence of invasiveness. RESULTS Non-invasive (n = 65) and invasive (n =...
متن کاملEffect of embolisation of meningioma on Ki-67 proliferation index.
The proliferation indices (PIs) were determined in 33 meningiomas using two monoclonal antibodies to the Ki-67 antigen (Ki-67 and MIB1). PIs obtained using Ki-67 on frozen material were intermediate between the lowest and highest MIB1 PIs determined in paraffin wax sections. Preoperative embolisation did not influence Ki67 PI, but four of the 15 embolised tumours showed substantially increased ...
متن کاملClinical usefulness of the free web-based image analysis application ImmunoRatio for assessment of Ki-67 labelling index in breast cancer
AIMS Ki-67 is a prognostic marker in breast cancer; however, the use of the Ki-67 labelling index (LI) in clinical practice requires a consistent and easily accessible scoring method. The present study evaluated the use of the free internet-based image analysis program ImmunoRatio to score Ki-67 LI in breast cancer in comparison with manual counting. METHODS Ki-67 immunohistochemical detectio...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2011
ISSN: 0923-7534
DOI: 10.1093/annonc/mdq732