Is tubuloglomerular feedback a tool to prevent nephron oxygen deficiency?
نویسندگان
چکیده
منابع مشابه
Tubuloglomerular and connecting tubuloglomerular feedback during inhibition of various Na transporters in the nephron.
Afferent (Af-Art) and efferent arterioles resistance regulate glomerular capillary pressure. The nephron regulates Af-Art resistance via: 1) vasoconstrictor tubuloglomerular feedback (TGF), initiated in the macula densa via Na-K-2Cl cotransporters (NKCC2) and 2) vasodilator connecting tubuloglomerular feedback (CTGF), initiated in connecting tubules via epithelial Na channels (ENaC). Furosemide...
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Previously we developed a “minimal” mathematical model of the tubuloglomerular feedback (TGF) system in a short-looped nephron of the mammalian kidney. In that model, a hyperbolic partial differential equation (PDE) represented the advection and transepithelial transport of chloride in the thick ascending limb (TAL). The feedback response was represented by an empirical relationship that determ...
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THE MACULA DENSA CELLS COMPRISE the sensing component of the tubuloglomerular feedback (TGF) mechanism and respond to changes in tubular fluid composition by transmitting signals to the afferent arterioles thus regulating the preglomerular vascular resistance and filtered load to the tubules (14, 15). This intriguing mechanism has remained under intensive investigation, and the accrued evidence...
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VARIATIONS OF NaCl concentration in the macula densa region of the tubule between 20 and 60 mM/l cause inverse changes in glomerular filtration rate (GFR) that, for the most part, are the result of a progressive increase in afferent arteriolar resistance and a subsequent fall in glomerular capillary pressure (5). The reductions in capillary pressure and GFR are rapidly inducible and rapidly rev...
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Recently much interest lhas centered upon the measurement of single nephron filtration rate (SNGFR) and on the evaluation of its regtulation by means of an intrarenal feedback control mechanism. M\etlhods used by many authors seem to (liffer technically, wlhich may explain in part the conflicting results and the actual scatter of the (lata reported in the literature. It has been pointed out by ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1997
ISSN: 0085-2538
DOI: 10.1038/ki.1997.51