Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A
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چکیده
منابع مشابه
Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A.
The failure of blood vessels to revascularize ischemic neural tissue represents a significant challenge for vascular biology. Examples include proliferative retinopathies (PRs) such as retinopathy of prematurity and proliferative diabetic retinopathy, which are the leading causes of blindness in children and working-age adults. PRs are characterized by initial microvascular degeneration, follow...
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Delayed revascularization of ischemic neural tissue is a major impediment to preservation of function in central nervous system (CNS) diseases including stroke and ischemic retinopathies. Therapeutic strategies allowing rapid revascularization are greatly needed to reduce ischemia-induced cellular damage and suppress harmful pathologic neovascularization. However, key mechanisms governing vascu...
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After a spinal cord lesion, a myriad of axon growth inhibitors present in myelin and in the neural scar contribute to the failure of injured axons to regenerate. Class 3 semaphorins are repulsive axon guidance cues that are induced in the meningeal fibroblasts that infiltrate the neural scar. Most if not all injured spinal cord neurons, including neurons that form the corticospinal tract (CST),...
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The adult brain is extremely vulnerable to various insults. The recent discovery of neural progenitors in adult mammals, however, raises the possibility of repairing damaged tissue by recruiting their latent regenerative potential. Here we show that activation of endogenous progenitors leads to massive regeneration of hippocampal pyramidal neurons after ischemic brain injury. Endogenous progeni...
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Vascular endothelial growth factor (VEGF)-A is a well-known major chemoattractant driver of angiogenesis--the formation of new blood vessels from pre-existing ones. However, the repellent factors that fine-tune this angiogenic process remain poorly characterized. We investigated the expression and functional role of endothelial cell-derived semaphorin 3A (Sema3A) in retinal angiogenesis, using ...
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ژورنال
عنوان ژورنال: Blood
سال: 2011
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2010-10-311589