ISIS: interaction sites identified from sequence
نویسندگان
چکیده
منابع مشابه
ISIS: interaction sites identified from sequence
MOTIVATION Large-scale experiments reveal pairs of interacting proteins but leave the residues involved in the interactions unknown. These interface residues are essential for understanding the mechanism of interaction and are often desired drug targets. Reliable identification of residues that reside in protein-protein interface typically requires analysis of protein structure. Therefore, for ...
متن کاملRunning Title: Protein-Protein Interaction Sites Predicting Protein-Protein Interaction Sites From Amino Acid Sequence
We describe an approach for computational prediction of protein-protein interaction sites using a support vector machine (SVM) classifier. Interface residues and other surface residues were extracted from 115 proteins derived from a set of 70 heterocomplexes in PDB. The SVM classifier was trained to predict whether or not a surface residue is located in the interface based on the identity of th...
متن کاملPredicting Protein-Protein Interaction Sites From Amino Acid Sequence
We describe an approach for computational prediction of protein-protein interaction sites using a support vector machine (SVM) classifier. Interface residues and other surface residues were extracted from 115 proteins derived from a set of 70 heterocomplexes in PDB. The SVM classifier was trained to predict whether or not a surface residue is located in the interface based on the identity of th...
متن کاملPredicted protein-protein interaction sites from local sequence information.
Protein-protein interactions are facilitated by a myriad of residue-residue contacts on the interacting proteins. Identifying the site of interaction in the protein is a key for deciphering its functional mechanisms, and is crucial for drug development. Many studies indicate that the compositions of contacting residues are unique. Here, we describe a neural network that identifies protein-prote...
متن کاملDiscovering Protein-Protein Interaction Sites from Sequence and Structure
This chapter gives a comprehensive introduction of the sequence/structural features that are characteristic of protein-protein interaction sites and reviews state-of-the-art methodologies for protein-protein binding site prediction. Protein-protein interaction residues are largely responsible for mediating physical binding processes such as inhibitory effects through enzyme-inhibitor interactio...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2007
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btl303