Islet transplantation: a field on the move
نویسندگان
چکیده
منابع مشابه
Introducing a New Experimental Islet Transplantation Model using Biomimetic Hydrogel and a Simple High Yield Islet Isolation Technique
Background: Islet transplantation could be an ideal alternative treatment to insulin therapy for type 1 diabetes Mellitus (T1DM). This clinical and experimental field requires a model that covers problems such as requiring a large number of functional and viable islets, the optimal transplantation site, and the prevention of islet dispersion. Hence, the methods of choice for isolation of functi...
متن کاملUpdate on islet transplantation.
Clinical islet transplantation has progressed considerably over the past 12 years, and >750 patients with type 1 diabetes have received islet transplants internationally over this time. Many countries are beginning to accept the transition from research to accepted and funded clinical care, especially for patients with brittle control that cannot be stabilized by more conventional means. Major ...
متن کاملPancreatic islet transplantation: A review
457 ABSTRACT: Advances in pancreatic islet transplantation for the treatment of type 1 diabetes have occurred in the past decade. Successful transplantation using the Edmonton protocol has achieved glycemic stability and insulin independence in many recipients. However, the effect of islet transplantation on secondary complications of diabetes is still not clearly understood. The UBC Islet Tran...
متن کاملAdvances and Challenges in Islet Transplantation: Islet Procurement Rates and Lessons Learned from Suboptimal Islet Transplantation
The initial step in successful islet transplantation is procurement of healthy donor islets. Given the limited number of donor pancreata selected for islet isolation and that islets from multiple donors are typically required to obtain insulin independence, it is critical to improve pancreas procurement rates and yield of islets for transplantation. Islets are delicate microorgans that are susc...
متن کاملExperimental Islet Transplantation
Pancreatic islet transplantation is a promising treatment modality for patients with insulindependent diabetes. Besides whole pancreas transplantation, it is the only treatment that can make patients normoglycemic without risking episodes of hypoglycemia. It can also prevent, slow down and even reverse the development of secondary complications to diabetes. Compared to whole pancreas transplant...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2001
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/16.5.893