Isolation of a Human Endogenous Retroviral HERV-H Element with an Open env Reading Frame
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چکیده
منابع مشابه
Spliced human endogenous retroviral HERV-H env transcripts in T-cell leukaemia cell lines and normal leukocytes: alternative splicing pattern of HERV-H transcripts.
The majority of human endogenous retroviral HERV-H elements in the human genome have large deletions in pol and lack most of env, 5-10% are more or less complete with a potentially immunosuppressive transmembrane protein-encoding env region. Spliced HERV-H env transcripts were detected in T-cell leukaemia cell lines and lymphocytes from healthy blood donors by using RT-PCR. The transcripts all ...
متن کاملHuman endogenous retrovirus family HERV-K(HML-2) RNA transcripts are selectively packaged into retroviral particles produced by the human germ cell tumor line Tera-1 and originate mainly from a provirus on chromosome 22q11.21.
The human germ cell tumor line Tera-1 produces retroviral particles which are encoded by the human endogenous retrovirus family HERV-K(HML-2). We show here, by quantitative reverse transcriptase PCR, that HML-2 gag and env RNA transcripts are selectively packaged into Tera-1 retroviral particles, whereas RNAs from cellular housekeeping genes and from other HERV families (HERV-H and HERV-W) are ...
متن کاملEvidence of selection on the domesticated ERVWE1 env retroviral element involved in placentation.
The human endogenous retrovirus HERV-W multicopy family includes a unique proviral locus, termed ERVWE1, which contains gag and pol pseudogenes and has retained a full-length envelope open reading frame (ORF). This Env protein (syncytin) is a highly fusogenic membrane glycoprotein and has been proposed to be involved in hominoid placental physiology. To track the hallmarks of natural selection ...
متن کاملThe full-length envelope of an HERV-H human endogenous retrovirus has immunosuppressive properties.
We have demonstrated previously that the envelope proteins of a murine retrovirus (Moloney murine leukaemia virus) and a simian retrovirus (Mason-Pfizer monkey virus) have immunosuppressive properties in vivo. This property was manifested by the ability of the proteins, when expressed by tumour cells normally rejected by engrafted mice, to allow the envelope-expressing cells to escape immune re...
متن کاملERVWE 1 ( endogenous retroviral family W , Env ( C 7 ) , member 1 )
Hugo: ERVWE1 Other names: env; enverin; Env-W; HERV-W; HERV-W-ENV; HERV-W_7q21.2 provirus ancestral Env polyprotein precursor; HERV-7q; HERVW; Syncytin; Syncytin-1 Location: 7q21.2 Note: Sequences of retroviral origin represent about 8% of the human genome. There are at least 31 families of human endogenous retroviruses (HERVs). Each family derived from an independent infection of the germ line...
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ژورنال
عنوان ژورنال: Virology
سال: 1999
ISSN: 0042-6822
DOI: 10.1006/viro.1999.9750