Isotretinoin Oil-Based Capsule Formulation Optimization
نویسندگان
چکیده
منابع مشابه
Isotretinoin Oil-Based Capsule Formulation Optimization
The purpose of this study was to develop and optimize an isotretinoin oil-based capsule with specific dissolution pattern. A three-factor-constrained mixture design was used to prepare the systemic model formulations. The independent factors were the components of oil-based capsule including beeswax (X₁), hydrogenated coconut oil (X₂), and soybean oil (X₃). The drug release percentages at 10, 3...
متن کاملImproving bioavailability with a novel isotretinoin formulation (isotretinoin-Lidose).
Current practice guidelines recommend administration of oral isotretinoin with high-fat meals, which may pose issues with patient compliance. Isotretinoin-Lidose (Epuris™), approved by Health Canada in November 2012 and scheduled for commercial release June 2013, is based on novel lipid encapsulation technology (Lidose®) to enclose isotretinoin, thereby increasing drug absorption during fasted ...
متن کاملFormulation development and optimization of palm kernel oil esters-based nanoemulsions containing sodium diclofenac
Response surface methodology was employed to study the effect of formulation composition variables, water content (60%-80%, w/w) and oil and surfactant (O/S) ratio (0.17-1.33), as well as high-shear emulsification conditions, mixing rate (300-3,000 rpm) and mixing time (5-30 minutes) on the properties of sodium diclofenac-loaded palm kernel oil esters-nanoemulsions. The two response variables w...
متن کاملFormulation and In-vitro-evaluation of Isotretinoin Tablets
Isotretinoin (13-cis-Retinoic acid) is a poor water soluble drug, commonly used in the treatment of severe cases of acne. The aim of this project is to formulate isotretinoin in form of tablet and enhance its solubility and dissolution rate; by the use of formulations containing either surfactant (SLS and Tween20) or HP-β-CD. The critical micelle concentration for each surfactant was determined...
متن کاملMathematical Formulation of DMH-Based Inverse Optimization
PURPOSE To introduce the concept of dose-mass-based inverse optimization for radiotherapy applications. MATERIALS AND METHODS Mathematical derivation of the dose-mass-based formalism is presented. This mathematical representation is compared to the most commonly used dose-volume-based formulation used in inverse optimization. A simple example on digitally created phantom is presented. The pha...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Scientific World Journal
سال: 2013
ISSN: 1537-744X
DOI: 10.1155/2013/856967