Kinetics of calcium-dependent inactivation of calcium current in voltage-clamped neurones of Aplysia californica.
نویسندگان
چکیده
منابع مشابه
Calcium-induced inactivation of calcium current causes the inter-burst hyperpolarization of Aplysia bursting neurones.
A triphasic series of tail currents which follow depolarizing voltage-clamp pulses in Aplysia neurones L2-L6 was described in the preceding paper (Kramer & Zucker, 1985). In this paper, we examine the nature of the late outward component of the tail current (phase III) which generates the inter-burst hyperpolarization in unclamped cells. The phase III tail current does not reverse between -30 a...
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چکیده ندارد.
15 صفحه اولZn2+ blocks the voltage activated calcium current of Aplysia neurons.
We have investigated the effect of Zn2+ on voltage-activated calcium currents of Aplysia neurons, using conventional two-electrode voltage-clamp techniques. The peak of these currents was reversibly reduced by Zn2+ (50% reduction at 3.75 mM; total block at 20 mM), while the current-voltage relation and the activation and inactivation curves were shifted to depolarized voltages. The effects of Z...
متن کاملLead inhibits the voltage-activated calcium current of Aplysia neurons.
Lead is a potent and reversible inhibitor of the voltage-dependent calcium current of Aplysia neurons in a concentration range (1-1000 microM) similar to that which elicits toxic effects in man. The threshold for inhibition is 1 microM and the dissociation constant about 90 microM. The inhibition is due to reduction of the peak current amplitude, and not due to alteration of the voltage depende...
متن کاملMechanism of calcium-dependent inactivation of a potassium current in Aplysia neuron R15: interaction between calcium and cyclic AMP.
In the preceding paper (Kramer and Levitan, 1988), we presented evidence that an inwardly rectifying K+ current (IR) is inactivated by Ca2+ influx accompanying spontaneous bursting activity in the Aplysia neuron R15. In this paper we examine the mechanism that enables Ca2+ to inactivate IR. Since IR is enhanced by cyclic AMP in neuron R15 (Drummond et al., 1980; Benson and Levitan, 1983), we ex...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1984
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1984.sp015066