Knock Down of HMGA2 Suppresses Colorectal Cancer Progression through Inhibiting Angiogenesis via Compromising VEGFR2 Signaling in HUVECs

Colorectal cancer is one of the major public health issues worldwide due to its high mortality and morbidity. Angiogenesis fundamental step tumors transition from dormant malignant state it recognized as hallmarks cancer. High mobility group AT-hook 2 encodes a small non-histone chromatinassociated protein that can modulate transcription by altering chromatin architecture. Currently mechanism which involved in angiogenesis colorectal has not been clarified. The expression was analyzed immunohistochemistry, Western blotting bioinformatics methods. cBioPortal mExpress online tools were applied explore copy-number variation methylation patients. Single cell data gene omnibus used examine specific type contributed Lentivirus knock down cells human umbilical vein endothelial study angiogenesis. In current study, we first detected pattern patients evaluated clinical values for time showed copy number amplification up regulation By analyzing single found specifically regulated epithelial cells. Furthermore, knocking suppresses via dual vascular growth factor-A semaphorin 3A through inactivating factor receptor pathway might be promising prognostic marker target treating advanced