Lamin B2 Modulates Nucleolar Morphology, Dynamics, and Function
نویسندگان
چکیده
منابع مشابه
Lamin B2 Modulates Nucleolar Morphology, Dynamics, and Function
The nucleolus is required for ribosome biogenesis. Human cells have 2 or 3 nucleoli associated with nucleolar organizer region (NOR)-bearing chromosomes. An increase in number and altered nucleolar morphology define cancer cells. However, the mechanisms that modulate nucleolar morphology and function are unclear. Here we show that in addition to localizing at the nuclear envelope, lamin B2 loca...
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T he nuclear envelope (NE) embraces the genome with a rich tapestry of outer and inner membrane proteins, some of which mechanically link the cytoskeleton to the nucleoskeleton (1). The nucleoskeleton includes the nuclear intermediate filaments, formed by independent networks of Aand B-type lamins. Humans have one gene (LMNA) encoding A-type lamins and two genes encoding B-type lamins (LMNB1 an...
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Lamins B1 and B2 (B-type lamins) have very similar sequences and are expressed ubiquitously. In addition, both Lmnb1- and Lmnb2-deficient mice die soon after birth with neuronal layering abnormalities in the cerebral cortex, a consequence of defective neuronal migration. The similarities in amino acid sequences, expression patterns, and knockout phenotypes raise the question of whether the two ...
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Lamin B1 and lamin B2 are essential building blocks of the nuclear lamina, a filamentous meshwork lining the nucleoplasmic side of the inner nuclear membrane. Deficiencies in lamin B1 and lamin B2 impair neurodevelopment, but distinct functions for the two proteins in the development and homeostasis of the CNS have been elusive. Here we show that embryonic depletion of lamin B1 in retinal proge...
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Unlike in prokaryotes and simple eukaryotes such as Saccharomyces cerevisiae, the origins of DNA replication (oris) in mammalian cells are not dictated by a specific nucleotide sequence. Nevertheless, recent studies show that mammalian replicons are organized in groups of site-specific but flexible replication oris, for which chromatin context plays an important role. Despite that our knowledge...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2017
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.00274-17