Laminitis in ponies is a diabetic‐like state

Evaluation of genetic and metabolic predispositions and nutritional risk factors for pasture-associated laminitis in ponies.

OBJECTIVE To evaluate genetic and metabolic predispositions and nutritional risk factors for development of pasture-associated laminitis in ponies. DESIGN Observational cohort study. ANIMALS 160 ponies. PROCEDURES A previous diagnosis of laminitis was used to differentiate 54 ponies (PL group) from 106 nonlaminitic ponies (NL group). Pedigree analysis was used to determine a mode of inher...

Nitric oxide donors as treatment for grass induced acute laminitis in ponies.

The potential for participation of the arginine-nitric oxide system in the aetiology of acute equine laminitis has been assessed. Nitric oxide (NO), produced by the action of NO synthase (NOS) on its substrate l-arginine, relaxes vascular smooth muscle to cause vasodilation. An attenuated normal vasodilatory tone may characterise the pathogenesis of acute equine laminitis. An intravenous infusi...

Endocrinopathic Laminitis, Obesity-Associated Laminitis, and Pasture-Associated Laminitis

In a recent online survey, we asked equine practitioners to list the three most common causes of laminitis in horses seen within their practice. We expected veterinarians to list colitis, colic, and retained placenta as the primary causes of laminitis, but many respondents listed obesity, insulin resistance (IR), equine metabolic syndrome (EMS), pituitary pars intermedia dysfunction (PPID), and...

Mechanisms of Pain in Laminitis

Equine Laminitis: A Revised Pathophysiology

Vasodilation precedes the development of carbohydrate overload laminitis. Circulating laminitis trigger factors activate lamellar enzymes, which lyse the attachments between the distal phalanx and the inner hoof wall. The clinical signs of laminitis occur when the lamellar architecture disintegrates. The amount of pain correlates with the extent of lamellar pathology. A substance produced by St...