Large-Scale Population Study of Human Cell Lines Indicates that Dosage Compensation is Virtually Complete
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Large-Scale Population Study of Human Cell Lines Indicates that Dosage Compensation Is Virtually Complete
X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing. We have carried out a large-scale analysis of gene expression in lymphoblastoid cell lines from four human populations to determine the extent to which escape from X chromosome inactivati...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2005
ISSN: 1553-7390,1553-7404
DOI: 10.1371/journal.pgen.0040009.eor