Launching Hsp70 neuroprotection
نویسندگان
چکیده
منابع مشابه
Launching Hsp70 neuroprotection
A large number of neurodegenerative disorders are triggered by the aggregation of misfolded proteins called amyloids. The main pathogenic event in these proteinopathies is the accumulation of oligomers, soluble assemblies that can disrupt synaptic activity, alter intracellular signaling, and spread to neighboring cells. Thus, preventing the formation of oligomers is a common therapeutic strateg...
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Dietary supplementation with antioxidant rich foods can decrease the level of oxidative stress in brain regions and can ameliorate age-related deficits in neuronal and behavioral functions. We examined whether short-term supplementation with blueberries might enhance the brain's ability to generate a heat shock protein 70 (HSP70) mediated neuroprotective response to stress. Hippocampal (HC) reg...
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BACKGROUND AND PURPOSE This study investigated the effects of intravenous recombinant Fv-Hsp70 protein on infarction volume and behavior after experimental ischemic stroke. METHODS Focal cerebral ischemia was produced by occluding the middle cerebral artery using the intraluminal suture technique. Rats subjected to 2 hours of focal ischemia were allowed to survive 24 hours. At 2(1/4) hours an...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2014
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.29148