LDL cholesterol performance of beta quantification reference measurement procedure
نویسندگان
چکیده
منابع مشابه
Performance of a direct LDL-cholesterol method compared to beta quantification
Low-density lipoprotein cholesterol is currently estimated by clinical laboratories using the Friedewald formula which requires fasting specimens and is subject to error with increasing uiglyceride levels. We describe a rapid method for isolating low-density lipoproteins by immunoseparation for subsequent measurement of cholesterol by enzymatic assay. The Direct LDLTM Immunoseparation Reagent m...
متن کاملDirect Measurement of LDL Cholesterol
able amounts of radiolabeled dextran in the plasma protein fraction [15]. Consequently, we do not think this mechanism plays a substantial role in producing the lower than expected dextran concentrations seen in the present study. The dextran we used had a mean molecular mass of 70 000 Da. Thus, some quantity of lower-molecular-mass dextran could have leaked out of the vascular space and distri...
متن کاملSeven direct methods for measuring HDL and LDL cholesterol compared with ultracentrifugation reference measurement procedures.
BACKGROUND Methods from 7 manufacturers and 1 distributor for directly measuring HDL cholesterol (C) and LDL-C were evaluated for imprecision, trueness, total error, and specificity in nonfrozen serum samples. METHODS We performed each direct method according to the manufacturer's instructions, using a Roche/Hitachi 917 analyzer, and compared the results with those obtained with reference mea...
متن کاملCandidate Reference Measurement Procedure for the Quantification of Total Serum Cortisol with LC-MS/MS.
BACKGROUND Accurate measurement of serum cortisol is required to diagnose and treat adrenal disorders. Although certified reference materials (CRMs) are available to standardize cortisol measurements, External Quality Assessment (EQA) schemes still demonstrate a wide dispersion of results. We present a serum cortisol candidate reference measurement procedure that, through analysis of a Joint Co...
متن کاملPerformance of four homogeneous direct methods for LDL-cholesterol.
BACKGROUND Homogeneous LDL-cholesterol methods from Genzyme, Reference Diagnostics, Roche, and Sigma were evaluated for precision, accuracy, and specificity for LDL in the presence of abnormal lipoproteins. METHODS Each homogeneous method was performed by a Roche/Hitachi 911 according to the vendors' instructions, and the results were compared with the beta-quantification reference method. We...
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ژورنال
عنوان ژورنال: Clinica Chimica Acta
سال: 2014
ISSN: 0009-8981
DOI: 10.1016/j.cca.2014.02.018