Left ventricular shape index and eccentricity index assessed by gated PET/CT. Promising parameters for detection of left ventricular remodelling

Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main source(s): University Groningen/University Medical Center Groningen. Background Left ventricular (LV) remodelling has been described as the pathway that precedes heart failure. This process consists changes in shape, size, volume and function left ventricle; all this directly associated to increased risk major adverse cardiac events (MACEs). Different parameters are used evaluate geometry multiple imaging modalities. In nuclear medicine, LV can be studied through shape index (SI) eccentricity (EI). These values examine degree sphericity elongation (EI) ventricle. However, perfusion PET/CT, not extensively with SI EI values, their role is yet elucidated. Purpose project aim describe patients examined by gated 13N-ammonia PET/CT ischemic infarction scenario. Methods We retrospectively randomly selected 140 referred between 2016 2022 for suspected or diagnosed CAD. The were classified 4 groups 35 according presence burden ischemia infarction: normal=0% scar burden; mild ischemia=5–10% moderate-severe ischemia≥10% infarction≥5% burden. collected information regarding myocardial flows (myocardial blood flow (MBF) at rest, hyperaemic MBF stress coronary reserve (CFR)) (SI end-diastolic rest stress, end-systolic stress). All variables automatically processed QPS/QGS software. performed a multicomparison analysis mentioned One way ANOVA variance Dunnett’s Test Post Hoc, stablishing control group. Results study population consisted 35.7% women, over 36 years old, no significant differences factors. group showed important when compared groups. With maximum change 0.090 observed group, minimum −0.041 Control subjects had statistically higher (p<0.001) (p = 0.005), 0.001)and lower other Additionally, follow linear proportional extend (Figure 1 2). Conclusions(s) seem clinically relevant early detection remodeling. there still research do establishing cut-off evaluating prediction MACEs.