Lentinan administration alleviates diarrhea of rotavirus-infected weaned pigs via regulating intestinal immunity

Abstract Background Lentinan (LNT) may regulate many important physiological functions of human and animals. This study aimed to verify whether LNT administration could relieve diarrhea via improving gut immunity in rotavirus (RV)-challenged weaned pigs. Methods Twenty-eight pigs were randomly fed 2 diets containing 0 or 84 mg/kg product for 19 d ( n = 14). RV infection was executed on 15. After extracting polysaccharides from product, its major monosaccharides analyzed. Then, polysaccharide used administrate RV-infected IPEC-J2 cells. Results Dietary supplementation supported normal function piglets even when infected with RV, as reflected by reduced growth performance loss prevalence, maintained P < 0.05). The isolated which molecular weight 5303 Da, included glucose, arabinose galactose. In cells, this significantly increased cell viability 0.05), anti-virus regulating pattern recognition receptors host defense peptides Conclusion Those results suggest that increases the piglets’ resistance RV-induced stress, likely supporting intestinal immunity.