Light-Triggered Myosin Activation for Probing Dynamic Cellular Processes
نویسندگان
چکیده
منابع مشابه
Light-triggered myosin activation for probing dynamic cellular processes.
Myosin II is an ATPase motor protein essential for many cellular functions including cell migration and division. In nonmuscle cells, myosin modulates protrusions at the leading edge and promotes retraction at the trailing edge during migration, while during cytokinesis, myosin is required for contraction of the cleavage furrow. For nonmuscle myosin, these varied functions are regulated by phos...
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Although several myofilament proteins are modified by protein phosphorylation, the 18-kDa myosin light chain 2 (MLC2) has special significance. In striated muscle, after some experimental struggles, MLC2 phosphorylation was shown to modulate myofilament activation by Ca.1 However, in the case of smooth muscle, phosphorylation of the MLC2 by a Ca calmodulin–dependent kinase triggers contraction....
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Myosin II is an actin-binding protein composed of MHC (myosin heavy chain) IIs, RLCs (regulatory light chains) and ELCs (essential light chains). Myosin II expressed in non-muscle tissues plays a central role in cell adhesion, migration and division. The regulation of myosin II activity is known to involve the phosphorylation of RLCs, which increases the Mg2+-ATPase activity of MHC IIs. However...
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Myosin light chain (MLC) phosphorylation plays important roles in various cellular functions such as cellular morphogenesis, motility, and smooth muscle contraction. MLC phosphorylation is determined by the balance between activities of Rho-associated kinase (Rho-kinase) and myosin phosphatase. An impaired balance between Rho-kinase and myosin phosphatase activities induces the abnormal sustain...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2011
ISSN: 1433-7851
DOI: 10.1002/anie.201100674