LIGHT‐deficiency impairs CD8+ T cell expansion, but not effector function
نویسندگان
چکیده
منابع مشابه
LIGHT-deficiency impairs CD8+ T cell expansion, but not effector function.
LIGHT, a newly identified member of the tumor necrosis factor (TNF) family, is expressed on activated T lymphocytes. To evaluate how LIGHT contributes to T cell functions, we generated LIGHT-deficient (LIGHT(-/-)) mice using gene targeting. Disruption of LIGHT significantly reduced CD8(+) T cell-cycle progression, leading to reduced proliferation to anti-CD3, anti-CD3/anti-CD28 or allogeneic st...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2003
ISSN: 1460-2377,0953-8178
DOI: 10.1093/intimm/dxg082