Limitations of the Reiter Protein Complement-Fixation (RPCF) Test

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Specificity and sensitivity of the Reiter protein complement-fixation (RPCF) test. Report on 1,400 selected sera.

The reliability of the sero-diagnosis of syphilis depends on the specificity and the sensitivity of the tests used. The specificity of a test is determined by the nature of the antigen; the sensitivity depends mainly on the technique by which the test is performed. The most specific though not the most sensitive test at the moment is, without doubt, the T. pallidum immobilization (TPI) test of ...

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Assessment of the Reiter Protein Complement-fixation (rpcf) Test in a Routine Serological

At St. Thomas's Hospital we were led to try the RPCF test by the preliminary report of De Bruijn (1957), in which he showed with 116 syphilitic sera that this test was considerably more sensitive than the Wassermann reaction (WR). The technique appeared simple, the antigen was available commercially and the test was in no way difficult for the routine laboratory. De Bruijn gave no precise detai...

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False positive reactions to the Reiter protein complement-fixation (RPCF) test.

As previously reported (Pillot, Betz, Colombani, and Ripault, 1965), the Reiter Protein ComplementFixation (RPCF) test gives false positive reactions in 0 05 to 0 5 per cent. of cases as a consequence of an antipolysaccharide antibody present in the serum of some individuals. Since, during the years 1960-67, we have performed this test routinely on every patient hospitalized in our clinic, we h...

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Specificity and Sensitivity of the Reiter Protein Complement - Fixation ( Rpcf ) Test *

The reliability of the sero-diagnosis of syphilis depends on the specificity and the sensitivity of the tests used. The specificity of a test is determined by the nature of the antigen; the sensitivity depends mainly on the technique by which the test is performed. The most specific though not the most sensitive test at the moment is, without doubt, the T. pallidum immobilization (TPI) test of ...

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Performance and use of the Reiter protein complement-fixation (RPCF) test.

The immunological basis for the use of the RPCF test in the sero-diagnosis of syphilis is the fact that Treponema pallidum and Treponema reiteri share a genus-specific protein antigen. Although the Reiter protein antigen appears to be a lipo-polysaccharideprotein complex (de Bruijn, 1959), it has been assumed that only the protein component is responsible for the reactivity with syphilitic seru...

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ژورنال

عنوان ژورنال: Sexually Transmitted Infections

سال: 1962

ISSN: 1368-4973

DOI: 10.1136/sti.38.3.131