Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency
نویسندگان
چکیده
منابع مشابه
Reprogramming of human fibroblasts to pluripotency with lineage specifiers.
Since the initial discovery that OCT4, SOX2, KLF4, and c-MYC overexpression sufficed for the induction of pluripotency in somatic cells, methodologies replacing the original factors have enhanced our understanding of the reprogramming process. However, unlike in mouse, OCT4 has not been replaced successfully during reprogramming of human cells. Here we report on a strategy to accomplish this re...
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Background: The efficiency of in vitro fertilization (IVF) is still low to be developed to blastocyst stage probably because of environmental conditions. It is likely that in vitro environment can not exactly mimic in vivo environment due to differences in media, metabolic content, atmospheric composition, temperature and pH. Therefore it may affect embryo quality by changing in embryo gene exp...
متن کاملThe Current State of Naïve Human Pluripotency
Naïve or ground state pluripotency is a cellular state in vitro which resembles cells of the preimplantation epiblast in vivo. This state was first observed in mouse embryonic stem cells and is characterized by high rates of proliferation, the ability to differentiate widely, and global hypomethylation. Human pluripotent stem cells (hPSCs) correspond to a later or "primed" stage of embryonic de...
متن کاملHuman Lineage-Specific Gene Inactivation
Pseudogenes are nonfunctional vestiges of genes. Investigating genes that were inactivated specifically on the human lineage or within humans can reveal the genetic basis of interspecies differences between humans and chimpanzees and interindividual differences within humans. It can also help understand the selective pressures that altered during human evolution or vary among human populations....
متن کاملCortical thickness is influenced by regionally specific genetic factors.
BACKGROUND Although global brain structure is highly heritable, there is still variability in the magnitude of genetic influences on the size of specific regions. Yet, little is known about the patterning of those genetic influences, i.e., whether the same genes influence structure throughout the brain or whether there are regionally specific sets of genes. METHODS We mapped the heritability ...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2017
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2017.03.036