Linkage analysis in alcohol dependence
نویسندگان
چکیده
منابع مشابه
Linkage analysis of alcohol dependence symptoms in the community.
BACKGROUND We have previously identified suggestive linkage for alcohol consumption in a community-based sample of Australian adults. In this companion paper, we explore the strength of genetic linkage signals for alcohol dependence symptoms. METHODS An alcohol dependence symptom score, based on DSM-IIIR and DSM-IV criteria, was examined. Twins and their nontwin siblings (1,654 males, 2,518 f...
متن کاملA joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder.
BACKGROUND A large linkage peak for alcohol dependence (AD) was detected on chromosome 4q in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). Are the susceptibility genes underlying this peak specific for AD or do they increase risk for externalizing disorders more generally? Can we, in the IASPSAD, replicate prior evidence for linkage to conduct disorder (CD)? METHODS The 7...
متن کاملA genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence.
Neuroticism is a personality trait which reflects individual differences in emotional stability and vulnerability to stress and anxiety. Consistent evidence shows substantial genetic influences on variation in this trait. The present study seeks to identify regions containing susceptibility loci for neuroticism using a selected sib-pair sample from Ireland. Using Merlin regress, we conducted a ...
متن کاملGenome-wide linkage scans for major depression in individuals with alcohol dependence.
Major depression is more prevalent among individuals with alcoholism than in the general population. Twin studies have found a moderate degree of genetic correlation for alcohol dependence (AD) and major depression (MD), suggesting the existence of loci that confer susceptibility to both disorders. The aim of the present study was to conduct genome-wide linkage analyses to identify loci and to ...
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ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 1999
ISSN: 0741-0395
DOI: 10.1002/gepi.1370170768