Lipid Membrane Interaction of Amyloidogenic Peptides
نویسندگان
چکیده
منابع مشابه
Principles governing oligomer formation in amyloidogenic peptides.
Identifying the principles that describe the formation of protein oligomers and fibrils with distinct morphologies is a daunting problem. Here we summarize general principles of oligomer formation gleaned from molecular dynamics simulations of Abeta-peptides. The spectra of high free energy structures sampled by the monomer provide insights into the plausible fibril structures, providing a rati...
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Aggregation of disordered amyloidogenic peptides into oligomers is the causative agent of amyloid-related diseases. In solution, disordered protein states are characterized by heterogeneous ensembles. Among these, β-rich conformers self-assemble via a conformational selection mechanism to form energetically-favored cross-β structures, regardless of their precise sequences. These disordered pept...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2018
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2018.32.1_supplement.lb178