Liver fibrosis markers in alcoholic liver disease

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Systematic review of the diagnostic performance of serum markers of liver fibrosis in alcoholic liver disease

BACKGROUND Alcoholic liver disease (ALD) is a significant cause of death and morbidity. Detection of liver fibrosis at an early stage could provide opportunities for more optimal management. Serum markers of liver fibrosis offer an alternative to biopsy. Evidence of the performance of biomarkers in ALD is needed and a systematic review to evaluate available studies was conducted. METHODS Elec...

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Hepatic fibrosis in patients with non-alcoholic fatty liver disease is associated with progression of the disease. In the present study, we analyzed the discriminative ability of serum laminin, type IV collagen and hyaluronan levels to predict the presence of fibrosis in these patients. In this preliminary report, we studied 30 overweight patients divided into two groups according to the absenc...

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ALCOHOLIC LIVER DISEASE Liver fibrosis is the common consequence of chronic liver injury of wide etiology

Liver fibrosis represents a significant health problem worldwide for which no effective therapy exists. A great deal of research has been carried out to understand the molecular mechanisms responsible for the development of liver fibrosis. Activated stellate cells are the primary cell type responsible for the production of collagen I, the key protein involved in the development of liver fibrosi...

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ژورنال

عنوان ژورنال: World Journal of Gastroenterology

سال: 2014

ISSN: 1007-9327

DOI: 10.3748/wjg.v20.i25.8018