Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model
نویسندگان
چکیده
منابع مشابه
Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model.
The numerous nonmyocytes present within the myocardium may establish electrical connections with myocytes through gap junctions, formed naturally or as a result of a cell therapy. The strength of the coupling and its potential impact on action potential characteristics and conduction are not well understood. This study used computer simulation to investigate the load-induced electrophysiologica...
متن کاملThe Relevance of Non-excitable Cells for Cardiac Pacemaker Function and Repolarization: Insights from a Microstructure Model Loading Effect of Fibroblast-myocyte Coupling on Resting Potential, Impulse Propagation
[PDF] [Full Text] [Abstract] , December 1, 2007; 585 (2): 565-578. J. Physiol. J. P. Fahrenbach, R. Mejia-Alvarez and K. Banach The relevance of non-excitable cells for cardiac pacemaker function [PDF] [Full Text] [Abstract] , February 1, 2008; 294 (2): H1010-H1017. Am J Physiol Heart Circ Physiol K. B. Walsh and J. Zhang regulation of a transient outward current by protein kinase C Neonata...
متن کاملa head parameter survey on mazandarani dialect and its effect(s) on learning english from ca perspective (on the basis of x-bar syntax)1
there has been a gradual shift of focus from the study of rule systems, which have increasingly been regarded as impoverished, … to the study of systems of principles, which appear to occupy a much more central position in determining the character and variety of possible human languages. there is a set of absolute universals, notions and principles existing in ug which do not vary from one ...
15 صفحه اولCardiac alternans induced by fibroblast-myocyte coupling: mechanistic insights from computational models.
Recent experimental studies have shown that fibroblasts can electrotonically couple to myocytes via gap junctions. In this study, we investigated how this coupling affects action potential and intracellular calcium (Ca(i)) cycling dynamics in simulated fibroblast-myocyte pairs and in two-dimensional tissue with random fibroblast insertions. We show that a fibroblast coupled with a myocyte gener...
متن کاملModelling cardiac fibroblasts: interactions with myocytes and their impact on impulse propagation.
AIMS Existence of myocyte-fibroblast coupling in the human heart is still a controversial question. This study aims at investigating in a biophysical model how much coupling would be necessary to perturb significantly the electrical propagation of the cardiac impulse. METHODS AND RESULTS A one-dimensional model representing a strand of myocytes covered by a layer of fibroblasts was formulated...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2008
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.01298.2007