Local Ocular Immunotherapy for Experimental Allergic Conjunctivitis
نویسندگان
چکیده
منابع مشابه
Local ocular immunotherapy for experimental allergic conjunctivitis.
PURPOSE We studied the efficacy of eyedrops as local ocular immunotherapy against experimental allergic conjunctivitis. METHODS Guinea pigs were sensitized with an intraperitoneal injection of ovalbumin (OA). Three weeks after the sensitization, a low concentration (10 microg/mL) of OA eyedrops was administered once a day for 3 weeks. Six weeks after the sensitization, an allergic inflammatio...
متن کاملSublingual immunotherapy for allergic rhinitis and conjunctivitis.
Sublingual immunotherapy (SLIT) for allergic respiratory diseases was first described in 1986 and immediately appeared as a viable alternative to the traditional subcutaneous route. Since then, more than 60 randomized controlled trials have been published, almost all with very favorable results. The average improvement over placebo in symptom score and medication use was always greater than 20%...
متن کاملSublingual immunotherapy for experimental allergic conjunctivitis in a murine model induced by Dermatophagoides farinae allergen.
BACKGROUND Sublingual immunotherapy (SLIT) is a clinically effective treatment in allergic conjunctivitis (AC); however, the mechanism of the underlying pharmacodynamics remains unclear. Here, we investigate the efficacy and the mechanism of a sublingually administered Dermatophagoides farinae (Der f) vaccine in a murine AC model. METHODS A murine model of AC caused by Der f extract was devel...
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Correspondence : Mikio MIYATA at the above address. was given 2 days before the challenge, with variousconcentrationsbeingtested. Chloroform as trihalomethane in drinking water was administered for 2 days before the challenge. pDichlorobenzene was inhaled at one of several concentrations for 2 days before the challenge. The animals were sacrificed 30 min after the challenge by exsanguination un...
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The possibility of producing local hyposensitization by administering allergens via mucosal routes was envisaged at the beginning of 1900, and local nasal immunotherapy has been extensively studied since the 1970s. Presently, there are 21 randomized controlled trials being conducted with the most common allergens, consistently showing the clinical efficacy of local nasal immunotherapy for rhini...
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ژورنال
عنوان ژورنال: Japanese Journal of Ophthalmology
سال: 2000
ISSN: 0021-5155
DOI: 10.1016/s0021-5155(00)00279-3