Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes
نویسندگان
چکیده
منابع مشابه
Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes
Alteration of mitochondria-associated membranes (MAMs) has been proposed to contribute to the pathogenesis of Alzheimer's disease (AD). We studied herein the subcellular distribution, the processing, and the protein interactome of the amyloid-β protein precursor (AβPP) and its proteolytic products in MAMs. We reveal that AβPP and its catabolites are present in MAMs in cellular models overexpres...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2016
ISSN: 1387-2877,1875-8908
DOI: 10.3233/jad-160953