Localized Pseudoxanthoma Elasticum-like Changes on the Chin

Localized Pseudoxanthoma Elasticum-like Changes on the Chin.

Pseudoxanthoma elasticum (PXE) is a rare, inherited, multisystem disorder characterized by progressive calcification and fragmentation of elastic fibers. Typically, small, yellowish papules are located on the neck and flexural areas; however, localized acquired cutaneous PXE has been proposed as a non-heritable form of the disorder. We report a patient who had normal appearing skin on the chin ...

Prominent mental (chin) crease: a new sign of pseudoxanthoma elasticum.

Pseudoxanthoma elasticum (PXE) is an inherited disease with many systemic complications. Its diagnosis can be easily overlooked. The purpose of this study was to assess a new clinical sign of PXE. A total of 47 consecutive patients with PXE were examined for mental creases and compared with 47 age-matched control patients. Photographs were evaluated by a blinded investigator. Mental creases wer...

Pseudoxanthoma elasticum

Pseudoxanthoma elasticum (PXE) is a genetic metabolic disease with autosomal recessive inheritance caused by mutations in the ABCC6 gene. The lack of functional ABCC6 protein leads to ectopic mineralization that is most apparent in the elastic tissues of the skin, eyes and blood vessels. The clinical prevalence of PXE has been estimated at between 1 per 100,000 and 1 per 25,000, with slight fem...

Pseudoxanthoma elasticum

Pseudoxanthoma elasticum-like papillary dermal elastolysis*

An Bras Dermatol. 2017;92(6):891-900. According to the literature, hospitalization is required in some cases, which did not happen in our case because of the early intervention (Table 2).5 Considering a reduced risk of agranulocytosis development and in accordance with Carneiro et al. (2011),5 our aim was not to question DDS therapy for leprosy, but to stimulate clinical awareness of its risks ...