Longitudinal relaxation time editing for acetylcarnitine detection with 1 H‐MRS
نویسندگان
چکیده
منابع مشابه
Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection.
Animal models suggest that acetylcarnitine production is essential for maintaining metabolic flexibility and insulin sensitivity. Because current methods to detect acetylcarnitine involve biopsy of the tissue of interest, noninvasive alternatives to measure acetylcarnitine concentrations could facilitate our understanding of its physiological relevance in humans. Here, we investigated the use o...
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Introduction: Acetylcarnitine (ALCAR) is known to facilitate the influx and efflux of acetylgroups across the mitochondrial membrane and buffers an excess in acetylCoA in both cytosolic and mitochondrial compartments [1]. Acetylcarnitine is a necessary intermediate for mitochondrial acetate metabolism [2] and has been shown to easily cross the blood brain barrier and act as a neuroprotective ag...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2016
ISSN: 0740-3194,1522-2594
DOI: 10.1002/mrm.26149