Low dose of snake antivenom is as effective as high dose in patients with severe neurotoxic snake envenoming

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Low dose of snake antivenom is as effective as high dose in patients with severe neurotoxic snake envenoming.

The objective of this study was to evaluate the effects of two different dosage protocols on the outcome of patients with severe neurotoxic snake envenoming, using a retrospective analysis of patients admitted with a diagnosis of severe neurotoxic snake bite over a 4 year period. In the study, 55 snake bite victims requiring ventilatory support for severe neurotoxic envenoming received either 1...

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Does High Dose of Viperidae Snake Antivenom Show Higher Efficacy over Low Dose in Severe Envenoming?

Snake bites poisoning is considered as one of the most common causes of death in Saudi Arabia annually. This study aimed to evaluate the efficacy of administration of high doses of anti-snake venom (ASV) versus low doses in adult patients with severe Viperidae envenoming. Cases were collected retrospectively from Dammam poisoning center, Saudi Arabia throughout the years: 2010 and 2012. Low dos...

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Antivenom for Neuromuscular Paralysis Resulting From Snake Envenoming

Antivenom therapy is currently the standard practice for treating neuromuscular dysfunction in snake envenoming. We reviewed the clinical and experimental evidence-base for the efficacy and effectiveness of antivenom in snakebite neurotoxicity. The main site of snake neurotoxins is the neuromuscular junction, and the majority are either: (1) pre-synaptic neurotoxins irreversibly damaging the pr...

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Antivenom dosing in 35 patients with severe brown snake (Pseudonaja) envenoming in Western Australia over 10 years.

OBJECTIVE To investigate the doses of antivenom administered to adult patients with severe brown snake envenoming. DESIGN AND SETTING Review of charts from Western Australian adult teaching hospitals, December 1991 to December 2001. PATIENTS 35 patients with severe brown snake envenoming, defined prospectively as afibrinogenaemia (< 0.3 g/L) after a bite by a brown snake (genus Pseudonaja)....

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ژورنال

عنوان ژورنال: Emergency Medicine Journal

سال: 2005

ISSN: 1472-0205,1472-0213

DOI: 10.1136/emj.2004.020727