Low EGF in myeloablative allotransplantation: association with severe acute GvHD in BMT CTN 0402
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چکیده
منابع مشابه
Phase 3 clinical trial of steroids/mycophenolate mofetil vs steroids/placebo as therapy for acute GVHD: BMT CTN 0802.
Corticosteroids are the accepted primary therapy for acute graft-versus-host disease (GVHD), but durable responses are seen in only about half of the patients. Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0802, a phase 3 multicenter randomized double-blinded trial, was designed to test whether mycophenolate mofetil (MMF) plus corticosteroids was superior to corticosteroids alon...
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High-dose, posttransplantation cyclophosphamide (PTCy) reduces severe graft-versus-host disease (GVHD) after allogeneic blood or marrow transplantation (alloBMT), but the impact of PTCy on long-term, disease-specific outcomes is unclear. We conducted a retrospective study of 209 consecutive adult patients transplanted for acute myeloid leukemia (AML, n = 138), myelodysplastic syndrome (n = 28),...
متن کاملgastrointestinal bleeding, the first presentation of acute gvhd in two patients with thalassemia after bmt
engraftment by donor lymphocytes in an immunologically compromised host can result in donor t-cell activation against host major histocompatibility complex antigens, with resultant gvhd. the acute form of gvhd (agvhd) is characterized by erythroderma, cholestatic hepatitis, and enteritis. the intestinal symptoms of agvhd include crampy abdominal pain and watery diarrhea, often with blood. the c...
متن کاملChronic GvHD decreases antiviral immune responses in allogeneic BMT.
Chronic graft-versus-host disease (cGvHD) is associated with functional immunodeficiency and an increased risk of opportunistic infections in allogeneic bone marrow transplantation (BMT). We used a parent to F1 model of allogeneic BMT to test the hypothesis that cGvHD leads to impaired antigen-specific antiviral immunity and compared BM transplant recipients with cGvHD to control groups of allo...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2017
ISSN: 0268-3369,1476-5365
DOI: 10.1038/bmt.2017.89