Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk
نویسندگان
چکیده
منابع مشابه
Rare and low-frequency coding variants alter human adult height
Human height is a highly heritable, polygenic trait1,2. The contribution of common DNA sequence variation to inter-individual differences in adult height has been systematically evaluated through genome-wide association studies (GWAS). This approach has thus far identified 697 independent variants located within 423 loci that together explain around 20% of the heritability of height3. As is typ...
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BACKGROUND AND PURPOSE Intracerebral hemorrhage has a substantial genetic component. We performed a preliminary search for rare coding variants associated with intracerebral hemorrhage. METHODS A total of 757 cases and 795 controls were genotyped using the Illumina HumanExome Beadchip (Illumina, Inc, San Diego, CA). Meta-analyses of single-variant and gene-based association were computed. R...
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ژورنال
عنوان ژورنال: Cell
سال: 2020
ISSN: 0092-8674
DOI: 10.1016/j.cell.2020.01.002