Lowering Lipophilicity by Adding Carbon: AzaSpiroHeptanes, a logD Lowering Twist
نویسندگان
چکیده
منابع مشابه
frequency lowering
background and aim: it has been several decades since the technology of frequency lowering (fl) has been proposed. however, primary research has revealed no benefits regarding the use of this technique. currently, new methods for fl and improvement of perception of speech and fricative sounds have led to the application of these methods by numerous companies to produce hearing aids. in this stu...
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Thomas A. Buchanan,* Woemer P. Meehan,* Young Y. Jeng,t Dong Yang,* Timothy M. Chan,* Jerry L. Nadler,§ Steven Scott,§ Robert K. Rude,* and Willa A. Hsueh* *Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, School of Medicine and *Department of Toxicology, School of Pharmacy, University of Southern California Medical Center, Los Angeles, California 90033; and §Divisi...
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Atorvastatin calcium, the lipid lowering agent, is taken as a model drug characterized by poor water solubility and bioavailability. In this study an attempt was made for preparation of nanocrystals using high pressure homogenization. A number of stabilizers were included as well as polymers at different concentrations, and the formulations were homogenized for ten cycles at a pressure of 1000 ...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2019
ISSN: 1948-5875,1948-5875
DOI: 10.1021/acsmedchemlett.9b00248