LPA as a Paracrine Mediator of Adipocyte Growth and Function
نویسندگان
چکیده
منابع مشابه
Secretory, endocrine and autocrine/paracrine function of the adipocyte.
Obesity is a major public health problem in Western countries, and >55% of adult Americans are overweight or obese. A major contributor to the epidemic of obesity is the current environment, which is characterized by increased availability of high energy foods and decreased physical activity. Several studies also demonstrated that genetic susceptibility contributes to obesity in some population...
متن کاملIdentification of JAK2 as a Mediator of FIP1L1-PDGFRA-Induced Eosinophil Growth and Function in CEL
The Fip1-like1 (FIP1L1)-platelet-derived growth factor receptor alpha fusion gene (F/P) arising in the pluripotent hematopoietic stem cell (HSC),causes 14% to 60% of patients with hypereosinophilia syndrome (HES). These patients, classified as having F/P (+) chronic eosinophilic leukemia (CEL), present with clonal eosinophilia and display a more aggressive disease phenotype than patients with F...
متن کاملThe endothelium: paracrine mediator of aortic dissection.
F or more than 30 years, the endothelium has assumed increasingly greater importance in our understanding of the development of vascular pathology. This includes the discoveries that the endothelium releases the powerful vasodila-tor and antiplatelet mediators prostacyclin and nitric oxide, as well as its role in governing permeability, inflammation, and monocyte/macrophage infiltration of the ...
متن کاملHuman growth hormone and human prolactin function as autocrine/paracrine promoters of progression of hepatocellular carcinoma
The death rates of hepatocellular carcinoma (HCC) are extremely high due to the paucity of therapeutic options. Animal models and anecdotal clinical evidence indicate a potential role of hGH and hPRL in HCC. However, the prognostic relevance and the functional role of tumor expression of these hormones in human HCC are not defined. Herein, we analyzed the mRNA and protein expression of hGH and ...
متن کاملGenetic, Endocrine and Paracrine/Autocrine Aspects of Porcine Adipocyte Differentiation
An extracellular matrix surface enhances s-v cell proliferation and inhibits preadipocyte differentiation. Dexamethasone, however, can induce preadipocyte differentiation in cultures in ECM dishes. The mechanism(s) of the ECM inhibitory influence need to be elucidated. TGF-P inhibits and IGF-1 enhances preadipocyte differentiation but both growth factors enhance s-v cell profliferation. The fun...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2006
ISSN: 0077-8923,1749-6632
DOI: 10.1111/j.1749-6632.2000.tb06547.x