Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention

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Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention

Lung cancers remain one of the most common and deadly cancers in the world today (12.5% of newly diagnosed cancers) despite current advances in chemo- and radiation therapies. Often, by the time these tumors are diagnosed, they have already metastasized. These tumors demonstrate the classic hallmarks of cancer in that they have advanced defensive strategies allowing them to escape various stand...

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Identification of a Novel Tumor-Binding Peptide for Lung Cancer Through in-vitro Panning

Tumor-targeted therapies are playing growing roles in cancer research. The exploitation of these powerful therapeutic modalities largely depends on the discovery of tumor-targeting ligands. Phage display has proven a promising high throughput screening tool for the identification of novel specific peptides with high binding affinity to cancer cells. In the present study, we describe the use of ...

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1Department of Microbiology and Immunology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA 2Department of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY 1421, USA 3Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA 4Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA 5Department...

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ژورنال

عنوان ژورنال: Clinical and Developmental Immunology

سال: 2012

ISSN: 1740-2522,1740-2530

DOI: 10.1155/2012/160724