Luteolin Attenuates Airway Mucus Overproduction via Inhibition of the GABAergic System

Luteolin Attenuates Airway Mucus Overproduction via Inhibition of the GABAergic System

Airway mucus overproduction is one of the most common symptoms of asthma that causes severe clinical outcomes in patients. Despite the effectiveness of general asthma therapies, specific treatments that prevent mucus overproduction in asthma patients remain lacking. Recent studies have found that activation of GABAA receptors (GABAAR) is important for promoting mucus oversecretion in lung airwa...

Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma.

Airway hyperresponsiveness (AHR), goblet cell metaplasia, and mucus overproduction are important features of bronchial asthma. To elucidate the molecular mechanisms behind these pulmonary pathologies, we examined for genes preferentially expressed in the lungs of a murine model of allergic asthma by using suppression subtractive hybridization (SSH). We identified a gene called gob-5 that had a ...

Airway mucus.

Hypersecretion of mucus is a cardinal sign of airways inflammation. Normally, secretion of mucus is designed to protect the respiratory portion of the lung from injury, but in disease its chronic overproduction in large airways (bronchi) and its appearance in small conducting airways (bronchioles) may be detrimental. Its relevance to patient discomfort and infection is generally accepted, but i...

Inhibition of airway liquid secretion and its effect on the physical properties of airway mucus.

The combination of both Cl- and[Formula: see text] secretion inhibitors causes an accumulation of mucins within the submucosal gland ducts of acetylcholine (ACh)-treated bronchi [S. K. Inglis, M. R. Corboz, A. E. Taylor, and S. T. Ballard. Am. J. Physiol. 272 ( Lung Cell. Mol. Physiol. 16): L372-L377, 1997], suggesting indirectly that these agents block airway gland liquid secretion. The presen...

Mucus Overproduction Virus-Induced Airway Hyperreactivity and CXCR2 Regulates Respiratory Syncytial