Lymphocyte Migration: A new spin on lymphocyte homing
نویسندگان
چکیده
منابع مشابه
Lymphocyte Migration: A new spin on lymphocyte homing
New evidence confirms the multi-step model for leukocyte migration through endothelia, but with a twist. The selectins are not always required, and some lymphocyte subsets rely heavily on integrins for their migration to tissues.
متن کاملDendritic cell migration and lymphocyte homing imprinting.
For an effective adaptive immune response to occur, dendritic cells (DC), which are the most efficient antigen-presenting cells, must be able to sample the peripheral microenvironment and migrate towards secondary lymphoid organs (SLO) where they activate naive lymphocytes. Upon activation, lymphocytes proliferate and acquire the capacity to migrate to extralymphoid compartments. Although the m...
متن کاملLymphocyte homing: The scent of a follicle
The recent discovery of a receptor needed for lymphocyte migration into lymphoid follicles indicates that multiple chemoattractive gradients allow lymphocytes to navigate to specialized niches in lymphoid organs.
متن کاملLymphocyte migration studies.
For maintenance of immunity and tolerance, the organs and tissues of the organism are connected by migrating lymphoid cells. Understanding lymphocyte migration is essential for many disorders and diseases-- especially in the mucosa-lined organs. Detailed analyses of migrating lymphocytes have been performed in many species, especially in laboratory animals. However, important experiments in lym...
متن کاملRecirculation and Homing of Lymphocyte Subsets: Dual Homing Specificity
The p7-integrin subunit can pair with two a-chains, a4 and aE, and is expressed mainly on lymphocytes. As an a4-heterodimer it binds to the mucosal addressin MAdCAM-1, thus acting as a mucosal homing receptor. As an aE-heterodimer it binds to E-cadherin and is mainly found on intestinal intraepithelial lymphocytes. Consequently, p7 is mostly expressed on lymphocytes of the mucosal immune system...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 1995
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(95)00147-3