Lymphocytes and ischemia-reperfusion injury

Ischemia/Reperfusion Injury

This study assessed gentamicin's effects on ischemia/reperfusion renal injury to better understand when and how it worsens postischemic acute renal failure. Rats were subjected to 25 minutes of renal pedicle occlusion with and without preischemic (15-minute) or postischemic (15-minute or 8-hour) gentamicin treatment (100 mg/kg, by itself a subtoxic dose). Gentamicin's impact on hypoxia/reoxygen...

Ischemia-reperfusion injury and melatonin.

Hepatic ischemia-reperfusion injury.

24 Interferon regulatory factor-1 (IRF1) is a nuclear transcription factor that induces inflammatory 25 cytokine mediators and contributes to hepatic ischemia-reperfusion injury (I/R). Currently, no 26 strategies to mitigate IRF1-mediated liver damage exist. Interferon regulatory factor 2 (IRF2) is a 27 structurally similar endogenous protein that competes with IRF1 for DNA binding sites in IRF...

Ischemia-Reperfusion Injury and Anesthesia

1 Department of Anesthesiology, Intensive Care and Pain Medicine, Münster University Hospital, Albert-Schweitzer-Campus 1, Building A1, 48149 Münster, Germany 2Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Karadeniz Technical University, 61000 Trabzon, Turkey 3 Department of Intensive Care Adults, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherl...

Ceramide and Ischemia/Reperfusion Injury

Ceramide, a bioactive membrane sphingolipid, functions as an important second messenger in apoptosis and cell signaling. In response to stresses, it may be generated by de novo synthesis, sphingomyelin hydrolysis, and/or recycling of complex sphingolipids. It is cleared from cells through the activity of ceramidases, phosphorylation to ceramide-1-phosphate, or resynthesis into more complex sphi...