Lymphoplasmacytic lymphoma and a CD5+ lymphoproliferative process presenting as composite disease in the bone marrow: a report of two cases

Correct subclassification of B cell lymphoma requires integration histologic and immunohistochemical findings in addition to results flow cytometric immunophenotyping, cytogenetic analysis, molecular studies. Evaluation for the MYD88 L265P mutation staining LEF1 can be helpful workup small lymphomas. In this case report two diagnostically difficult cases, we present patients with lymphoplasmacytic (LPL) a CD5+ lymphoproliferative process presenting as composite disease within bone marrow. both ancillary studies biopsy at other sites careful review an expanded immunohistochemistry panel were important correct final classification.