m6A-epitranscriptome modulates memory strength
نویسندگان
چکیده
منابع مشابه
Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer
Recent studies that have emerged on the diversity of RNA modification in tumors suggest their eligibility as bona fide targets in diagnosis and drug discovery. N6-methyladenosine (m6A) was first reported and is most common in epitranscriptome modification of various RNAs. The YT521-B homology (YTH) domain family are representative m6A-binding proteins, but how the YTH domain family is involved ...
متن کاملArabidopsis m6A demethylase activity modulates viral infection of a plant virus and the m6A abundance in its genomic RNAs.
N6-methyladenosine (m6A) is an internal, reversible nucleotide modification that constitutes an important regulatory mechanism in RNA biology. Unlike mammals and yeast, no component of the m6A cellular machinery has been described in plants at present. m6A has been identified in the genomic RNAs of diverse mammalian viruses and, additionally, viral infection was found to be modulated by the abu...
متن کاملThe Arabidopsis epitranscriptome.
The most prevalent internal modification of plant messenger RNAs, N(6)-methyladenosine (m(6)A), was first discovered in the 1970s, then largely forgotten. However, the impact of modifications to eukaryote mRNA, collectively known as the epitranscriptome, has recently attracted renewed attention. mRNA methylation is required for normal Arabidopsis development and the first methylation maps revea...
متن کاملTranslating the epitranscriptome
RNA modifications are indispensable for the translation machinery to provide accurate and efficient protein synthesis. Whereas the importance of transfer RNA (tRNA) and ribosomal RNA (rRNA) modifications has been well described and is unquestioned for decades, the significance of internal messenger RNA (mRNA) modifications has only recently been revealed. Novel experimental methods have enabled...
متن کاملRevealing the Elusive Plant Epitranscriptome
RNA is decorated by various chemical modifications that affect the stability and localization of this fragilemolecule. These diverse, highly conserved, covalent modifications also help RNA perform its crucial roles in the cell. Over 100 RNAmodifications have been identified, primarily in noncoding RNAs (e.g., tRNA and rRNA). Less is known about the chemical modification of mRNA, although there ...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2018
ISSN: 1001-0602,1748-7838
DOI: 10.1038/s41422-018-0121-8