Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization
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چکیده
منابع مشابه
Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization
There is growing interest in studying and engineering integral membrane proteins (MPs) that play key roles in sensing and regulating cellular response to diverse external signals. A MP must be expressed, correctly inserted and folded in a lipid bilayer, and trafficked to the proper cellular location in order to function. The sequence and structural determinants of these processes are complex an...
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ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2017
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1005786