Macromolecule and water magnetization exchange modeling in articular cartilage
نویسندگان
چکیده
منابع مشابه
Modeling of Articular Cartilage Growth Using COMSOL
The articular cartilage in the human knee joint functions in a highly demanding mechanical environment and its degeneration or defects have been, recently, treated with localized metal implants. The cartilage was found to grow onto the implant in the animal experiments. To simulate the cartilage growth, we have developed an axisymmetric human knee model with metal implant filling the assumed de...
متن کاملPRG4 exchange between the articular cartilage surface and synovial fluid.
The boundary lubrication function of articular cartilage is mediated in part by proteoglycan 4 (PRG4) molecules, found both in synovial fluid (SF) and bound to the articular cartilage surface. Currently the mechanism by which PRG4 binds to the articular surface is not well understood. The objectives of this study were to determine (1) the effect of bathing fluid contents on PRG4 concentration a...
متن کاملArticular cartilage and changes in Arthritis: Collagen of articular cartilage
The extracellular framework and two-thirds of the dry mass of adult articular cartilage are polymeric collagen. Type II collagen is the principal molecular component in mammals, but collagens III, VI, IX, X, XI, XII and XIV all contribute to the mature matrix. In developing cartilage, the core fibrillar network is a cross-linked copolymer of collagens II, IX and XI. The functions of collagens I...
متن کاملMolecular Size Dependency of Water Macromolecule Exchange Induced Frequency Shift
Introduction: A recent study suggested that water macromolecule exchange (WME) processes can contribute to the in vivo gray matter (GM) and white matter (WM) contrast in high field phase imaging [1]. Due to the complex nature of macromolecule-water interaction, bovine serum albumin (BSA) was used as a model system to demonstrate this effect. It is assumed that the WME interaction depends on the...
متن کاملModeling the Insulin-Like Growth Factor System in Articular Cartilage
IGF signaling is involved in cell proliferation, differentiation and apoptosis in a wide range of tissues, both normal and diseased, and so IGF-IR has been the focus of intense interest as a promising drug target. In this computational study on cartilage, we focus on two questions: (i) what are the key factors influencing IGF-IR complex formation, and (ii) how might cells regulate IGF-IR comple...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2000
ISSN: 0740-3194,1522-2594
DOI: 10.1002/1522-2594(200012)44:6<840::aid-mrm4>3.0.co;2-k