Macrophage migration inhibitory factor in rheumatoid arthritis: clinical correlations

Macrophage migration inhibitory factor in rheumatoid arthritis: clinical correlations.

OBJECTIVE Cytokines play an important role in the pathology of rheumatoid arthritis (RA). Macrophage migration inhibitory factor (MIF) is a cytokine with a broad spectrum of actions, including induction of monocyte tumour necrosis factor alpha (TNF-alpha). Evidence of the expression and proinflammatory activity of MIF has recently been demonstrated in RA synovium and in animal models of RA. We ...

Macrophage migration inhibitory factor upregulates angiogenic factors and correlates with clinical measures in rheumatoid arthritis.

OBJECTIVE To investigate the relationship between macrophage migration inhibitory factor (MIF) levels and clinical measures in rheumatoid arthritis (RA), and the potential for regulation of angiogenesis in RA. METHODS Serum and synovial fluid (SF) levels of MIF and vascular endothelial growth factor (VEGF) in patients with RA were determined by sandwich ELISA, and the relationships among MIF,...

Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by destruction of bone and cartilage, which is mediated, in part, by synovial fibroblasts. Matrix metalloproteinases (MMPs) are a large family of proteolytic enzymes responsible for matrix degradation. Macrophage migration inhibitory factor (MIF) is a cytokine that induces the production of a large number of proinflammato...

Macrophage Migration Inhibitory Factor

Macrophage Migration Inhibitory Factor Induces Il-8 Productionin Synovial Fibroblasts of Rheumatoid Arthritis

INTRODUCTION Rheumatoid arthritis (RA) is an autoimmune disease that is characterized by severe synovitis and cartilage destruction. Synovial cells play a major role in the pathogenesis of RA through the synthesis of various cytokines, proteases, superoxide, etc. Interleukin-8 (IL-8), one of CXC chemokines, is known to recruit neutrophils into inflammatory loci. Chemokines have been reported to...