Malignant hyperthermia testing in probands with NO adverse anesthetic reaction
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چکیده
منابع مشابه
Malignant hyperthermia testing in probands with NO adverse anesthetic reaction
Background Malignant hyperthermia (MH) is characterized by an adverse reaction to volatile anesthetic, and/or succinylcholine. Typically, following an adverse anesthetic reaction or positive family history, patients will undergo caffeine-halothane contracture (CHCT) and/ or genetic testing. However, sometimes patients with no individual or family history of anesthetic reaction are referred for ...
متن کاملMalignant hyperthermia testing in probands without adverse anesthetic reaction.
BACKGROUND Malignant hyperthermia (MH) is triggered by reactions to anesthetics. Reports link nonanesthetic-induced MH-like reactions to a variety of disorders. The objective of the authors was to retrospectively investigate the reasons for referrals for MH testing in nonanesthetic cases and assess their phenotype. In addition, the response to the administration of oral dantrolene in nonanesthe...
متن کاملMalignant hyperthermia in Canada: characteristics of index anesthetics in 129 malignant hyperthermia susceptible probands.
BACKGROUND Between 1992 and 2011, 373 Canadian individuals with adverse anesthetic reaction were referred to the Malignant Hyperthermia Unit in Toronto, Ontario, Canada for malignant hyperthermia (MH) diagnostic testing. We analyzed the epidemiologic characteristics of the index adverse anesthetics for those probands who were confirmed to be MH susceptible. METHODS One hundred twenty-nine pro...
متن کاملMalignant Hyperthermia—Molecular Testing
Malignant hyperthermia (MH) is triggered by all inhalative anesthetics as well as depolarizing muscle relaxants in genetically predisposed individuals. Presymptomatic testing is important in this potentially fatal pharmacogenetic disease. In vitro challenging of muscle samples with halothane and caffeine is the basis of contracture testing, which until recently was the only accepted diagnostic ...
متن کاملHeat production during anesthetic-induced malignant hyperthermia.
Malignant hyperthermia (MH) is a pharmacogenetic disease which predisposes to the trigger of a life-threatening, hypermetabolic syndrome by potent inhaled anesthetics and by depolarizing skeletal muscle relaxants. Heat production in the anesthetized MH can be profound with 5-fold increases in oxygen consumption. The trigger anesthetics cause an abnormal, sustained rise in myoplasmic calcium lev...
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ژورنال
عنوان ژورنال: BMC Anesthesiology
سال: 2014
ISSN: 1471-2253
DOI: 10.1186/1471-2253-14-s1-a2