Mammalian Sirt1: insights on its biological functions
نویسندگان
چکیده
منابع مشابه
Impact of Sirt1 on mammalian aging
overexpression of the protein deacetylase Sir2 increases longevity [1]. Mammals possess 7 paralogs of the Sir2 gene, being Sirt1 the most similar one closest to Sir2 [1]. In our recent work [2], we have used a genetic approach to address the effect of Sirt1 on mammalian ageing. In particular, we have generated two independent lines of transgenic mice that globally overexpress Sirt1 (≈3-fold) un...
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Glycosylation of glycoproteins is one of many molecular changes that accompany malignant transformation. Post-translational modifications of proteins are closely associated with the adhesion, invasion, and metastasis of tumor cells. CD147, a tumor-associated antigen that is highly expressed on the cell surface of various tumors, is a potential target for cancer diagnosis and therapy. A signific...
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The NAD-dependent deacetylase SIR2 and the forkhead transcription factor DAF-16 regulate lifespan in model organisms, such as yeast and C. elegans. Here we show that the mammalian SIR2 ortholog SIRT1 deacetylates and represses the activity of the forkhead transcription factor Foxo3a and other mammalian forkhead factors. This regulation appears to be in the opposite direction from the genetic in...
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Maf1 is a nutrientand stress-sensitive global repressor of transcription by RNA polymerase (pol) III [1,2]. Its primary function in this context is to limit the synthesis of highly abundant 5S rRNA and tRNAs in response to nutrient availability and cellular stress [3]. Thus, Maf1 ensures the efficient use of metabolic resources while balancing the need for protein synthetic components during ce...
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ژورنال
عنوان ژورنال: Cell Communication and Signaling
سال: 2011
ISSN: 1478-811X
DOI: 10.1186/1478-811x-9-11