Management of Neuropsychiatric Systemic Lupus Erythematosus: Current Approaches and Future Perspectives

Management of Neuropsychiatric Systemic Lupus Erythematosus: Current Approaches and Future Perspectives.

Neuropsychiatric systemic lupus erythematosus (NPSLE) is a generic definition referring to a series of neurological and psychiatric symptoms directly related to systemic lupus erythematosus (SLE). NPSLE includes heterogeneous and rare neuropsychiatric (NP) manifestations involving both the central and peripheral nervous system. Due to the lack of a gold standard, the attribution of NP symptoms ...

Neuropsychiatric Systemic Lupus Erythematosus

Neuropsychiatric systemic lupus erythematosus (NPSLE) is the least understood, yet perhaps the most prevalent manifestation of lupus. The pathogenesis of NPSLE is multifactorial and involves various inflammatory cytokines, autoantibodies, and immune complexes resulting in vasculopathic, cytotoxic and autoantibody-mediated neuronal injury. The management of NPSLE is multimodal and has not been s...

Neuropsychiatric systemic lupus erythematosus: pathophysiology and the future of treatment

Systemic lupus erythematosus Systemic lupus erythematosus (SLE) is characterized by the presence of several autoantibodies, including anti-dsDNA antibodies [1,2]. Patients with SLE are affected with the following conditions: skin rash, arthritis, serositis, such as pericarditis and pleurisy, cytopenia, nephritis and neuropsychiatric (NP) symptoms. The prevalence of SLE ranges from 20 to 200 cas...

Current concepts of neuropsychiatric systemic lupus erythematosus (NP-SLE).

C1q Deficiency and Neuropsychiatric Systemic Lupus Erythematosus

C1q deficiency is a rare immunodeficiency, which is strongly associated with the development of systemic lupus erythematosus (SLE). A mutation in one of the C1q genes can either lead to complete deficiency or to low C1q levels with C1q polypeptide in the form of low-molecular weight (LMW) C1q. Patients with C1q deficiency mainly present with cutaneous and renal involvement. Although less freque...