Manganese superoxide dismutase activity regulates transitions between quiescent and proliferative growth
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منابع مشابه
Manganese superoxide dismutase activity regulates transitions between quiescent and proliferative growth.
In recent years, the intracellular reactive oxygen species (ROS) levels have gained increasing attention as a critical regulator of cellular proliferation. We investigated the hypothesis that manganese superoxide dismutase (MnSOD) activity regulates proliferative and quiescent growth by modulating cellular ROS levels. Decreasing MnSOD activity favored proliferation in mouse embryonic fibroblast...
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The mitochondrion is vital for many metabolic pathways in the cell, contributing all or important constituent enzymes for diverse functions such as β-oxidation of fatty acids, the urea cycle, the citric acid cycle, and ATP synthesis. The mitochondrion is also a major site of reactive oxygen species (ROS) production in the cell. Aberrant production of mitochondrial ROS can have dramatic effects ...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2008
ISSN: 1474-9718,1474-9726
DOI: 10.1111/j.1474-9726.2008.00384.x