Matrix Deposition Modulates the Viscoelastic Shear Properties of Hydrogel-Based Cartilage Grafts
نویسندگان
چکیده
منابع مشابه
Matrix deposition modulates the viscoelastic shear properties of hydrogel-based cartilage grafts.
Hydrogel-based scaffolds such as alginate have been extensively investigated for cartilage tissue engineering, largely due to their biocompatibility, ambient gelling conditions, and the ability to support chondrocyte phenotype. While it is well established that the viscoelastic response of articular cartilage is essential for articulation and load bearing, the time-dependent mechanical properti...
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Osteoarthritis (OA) is a disease that involves the erosion and structural weakening of articular cartilage. OA is characterized by the degradation of collagen and proteoglycans in the extracellular matrix (ECM), particularly at the articular surface by proteinases including matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs).(1) Degradat...
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Healing articular cartilage remains a significant clinical challenge because of its limited self-healing capacity. While delivery of autologous chondrocytes to cartilage defects has received growing interest, combining cell-based therapies with scaffolds that capture aspects of native tissue and promote cell-mediated remodeling could improve outcomes. Currently, scaffold-based therapies with en...
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15 صفحه اولViscoelastic properties of demineralized dentin matrix.
OBJECTIVES To evaluate the viscoelastic properties of demineralized dentin matrix. Stress-relaxation studies were done on matrices in tension and strain elongation or creep studies were done in both tension and compression. METHODS Mid-coronal dentin disks were prepared from extracted unerupted human third molars. Disks were 0.5 mm thick for stress-relaxation or tensile creep experiments and ...
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ژورنال
عنوان ژورنال: Tissue Engineering Part A
سال: 2011
ISSN: 1937-3341,1937-335X
DOI: 10.1089/ten.tea.2010.0379